Projecttitel: Glycaemic effects of infant nutrition at weaning
Kernthema: Gezond en Veilig
Looptijd: 2017 -2018
Projectleider: Sietse Jan Koopmans
Betrokken partijen: Company Beneo, Company Ellegaard, Nestec, Wageningen University & Research
Increasing evidence suggests that early life environment can influence health and disease later in life. Optimization of nutrition during infancy could decrease the risk of non-communicable diseases like obesity, diabeties and cardiovascular disease, thus having an important potential impact on public health and economy. The complementary feeding period consists on gradual diet diversification and decrease of breast-milk intake and usually goes from 6 to 24 months of age. During this stage the infant transitions from a low to a high carbohydrate diet which also varies in quality, thus influencing postprandial blodd glucose response. In adults, frequent consumption of high-postprandial-glucose-response diets is associated to greater risk of type 2 diabetes and cardiovascular disease. Up to now, the effect of carbohydrate choices in infants is not known. Several organs and systems are still in development at this stage and thus may be sensitive to be programmed. In this study, we hypothesize that diets promoting a high postprandial glucose response during the weaning period have a detrimental effect on metabolic health later in life, by affecting the microbiota, the energy balance, the endocrine pancreatic function and the cardiovascular system. The alterations will result in metabolic programming of obesity, type 2 diabetes and cardiovascular disease.
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