Projecttitel: Feasibility study for the development of a framework for safety and risk-benefit
Projectnummer: AF-13501
Kernthema: Gezond en Veilig
Looptijd: 2015-2016
Budget publiek: € 310.000
Budget privaat: € 55.000
Contactpersoon: Geert Houben
Projectpartners: Nutricia Research and TNO
Samenvatting
The immune system plays a crucial role in maintaining health. Immune disturbances can cause primary immune diseases (immunodeficiency or inflammatory diseases) and may result in increased susceptibility to infectious diseases and cancer. Immune and infiammatory mechanisms further play a key role in many more diseases and disorders, such as in the mechanisms of disease in obesity, geriatrics, mental disorders and toxicity in general. With the increase of populations concerned, immune related diseases are a major and increasing cause of loss of health, loss of quality of life and costs to society. Optimal immune health and prevention, early diagnosis, therapy and monitoring of immune health disturbances and immune diseases therefore are of major importance.
It is generally accepted that the immune health status is strongly determined during early life stages. Many immune related diseases are thought to find their origin in adverse shifts in immune balances during pregnancy or the first 2 to 3 years of life. Therefore, risk reduction measures or immune health interventions during these stages of life may be most effective and efficient in reducing the loss of health, loss of quality of life and costs to society due to immune related diseases and disorders. Several starting points for immune health interventions have been identified and are being developed into prophylactic or therapeutic approaches, particularly targeted at the early life states. However, these developments are strongly hampered due to the fact that there is no experience in how to assess the safety and risk-benefit balance of such interventions. The current project aims to investigate the feasibility and possible approach for the development of a framework for safety and risk benefit assessment for immune health interventions during early life stages.
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